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TargetGlucosylceramidase
LigandBDBM42389
Substrate/Competitorn/a
Meas. Tech.Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity
EC50>10000±n/a nM
Citation PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay(2008)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Glucosylceramidase
Name:Glucosylceramidase
Synonyms:Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GCase | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase)
Type:Enzyme
Mol. Mass.:59724.64
Organism:Homo sapiens (human)
Description:The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM42389
NameBDBM42389
Synonyms:6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-1-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]carboxylic acid ethyl ester | 6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylic acid ethyl ester | MLS000050713 | SMR000078187 | cid_2962025 | ethyl 6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-1H,1'H-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylate | ethyl 6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methylspiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylate | ethyl 6'-azanyl-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylate
TypeSmall organic molecule
Emp. Form.C21H22ClN5O3
Mol. Mass.427.884
SMILESCCOC(=O)N1CCC2(CC1)C(C#N)C(=N)Oc1c2c(C)nn1-c1cccc(Cl)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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