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Target
Apoptosis regulator Bcl-2
Ligand
BDBM32318
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
670±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM32318
Synonyms:
4-[[4-(2-methyl-3-imidazo[1,2-a]pyrimidinyl)-2-thiazolyl]amino]phenol;hydrobromide | 4-[[4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-1,3-thiazol-2-yl]amino]phenol;hydrobromide | 4-[[4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-yl]amino]phenol;hydrobromide | MLS000715643 | SMR000277160 | cid_5337459
Type:
Small organic molecule
Emp. Form.:
C16H13N5OS
Mol. Mass.:
323.372
SMILES:
Cc1nc2ncccn2c1-c1csc(Nc2ccc(O)cc2)n1
Structure:
Search PDB for entries with ligand similarity: