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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43398
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
10±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43398
Synonyms:
(E)-4-(2-sulfanylidene-1,3-benzoxazol-3-yl)-3-buten-2-one | (E)-4-(2-sulfanylidene-1,3-benzoxazol-3-yl)but-3-en-2-one | (E)-4-(2-thioxo-1,3-benzoxazol-3-yl)but-3-en-2-one | 4-(2-Thioxo-benzooxazol-3-yl)-but-3-en-2-one | MLS000569046 | SMR000173840 | cid_5749438
Type:
Small organic molecule
Emp. Form.:
C11H9NO2S
Mol. Mass.:
219.26
SMILES:
CC(=O)C=Cn1c2ccccc2oc1=S |w:4.4|
Structure:
Search PDB for entries with ligand similarity: