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Target
G2/mitotic-specific cyclin-B1
Ligand
BDBM43776
Substrate
n/a
Meas. Tech.
Counterscreen assay for inhibitors of Wee1 degradation: dose response cell-based assay to identify inhibitors of cyclin B degradation
EC50
>5527±n/a nM
Citation
 PubChem, PC Counterscreen assay for inhibitors of Wee1 degradation: dose response cell-based assay to identify inhibitors of cyclin B degradation PubChem Bioassay (2008)[AID] 
Target
Name:
G2/mitotic-specific cyclin-B1
Synonyms:
CCNB | CCNB1 | CCNB1_HUMAN
Type:
Enzyme Subunit
Mol. Mass.:
48340.95
Organism:
Homo sapiens (Human)
Description:
P14635
Residue:
433
Sequence:
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAKAVAKV
  
Inhibitor
Name:
BDBM43776
Synonyms:
(5Z)-2-anilino-5-[(1-methyl-2-pyrrolyl)methylidene]-4-thiazolone | (5Z)-2-anilino-5-[(1-methylpyrrol-2-yl)methylene]-2-thiazolin-4-one | (5Z)-2-anilino-5-[(1-methylpyrrol-2-yl)methylidene]-1,3-thiazol-4-one | (5Z)-5-[(1-methylpyrrol-2-yl)methylidene]-2-phenylazanyl-1,3-thiazol-4-one | 5-[1-(1-Methyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-2-[(E)-phenylimino]-thiazolidin-4-one | MLS000333177 | SMR000436531 | cid_941925
Type:
Small organic molecule
Emp. Form.:
C15H13N3OS
Mol. Mass.:
283.348
SMILES:
Cn1cccc1C=C1SC(Nc2ccccc2)=NC1=O |w:6.6,c:18|
Structure:
Search PDB for entries with ligand similarity: