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Target
Leucine--tRNA ligase
Ligand
BDBM43823
Substrate
n/a
Meas. Tech.
Binding Asssay
pH
7.5±0
Temperature
273.15±n/a K
Kd
1.1e+3± 1e+2 nM
Citation
 Llano-Sotelo, B; Azucena, EF; Kotra, LP; Mobashery, S; Chow, CS Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. Chem Biol 9:455-63 (2002) [PubMed]  Article 
Target
Name:
Leucine--tRNA ligase
Synonyms:
Aminoacyl-tRNA synthetase
Type:
PROTEIN
Mol. Mass.:
101024.31
Organism:
Thermus thermophilus
Description:
Q7SIE4
Residue:
878
Sequence:
MEKYNPHAIEAKWQRFWEEKGFMKAKDLPGGRGKQYVLVMFPYPSGDLHMGHLKNYTMGDVLARFRRMQGYEVLHPMGWDAFGLPAENAALKFGVHPKDWTYANIRQAKESLRLMGILYDWDREVTTCEPEYYRWNQWIFLKMWEKGLAYRAKGLVNWCPKCQTVLANEQVVEGRCWRHEDTPVEKRELEQWYLRITAYAERLLKDLEGLNWPEKVKAMQRAWIGRSEGAEILFPVEGKEVRIPVFTTRPDTLFGATFLVLAPEHPLTLELAAPEKREEVLAYVEAAKRKTEIERQAEGREKTGVFLGAYALNPATGERIPIWTADYVLFGYGTGAIMAVPAHDQRDYEFARKFGLPIKKVIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRKVIAWLEEKGLGKGRVTYRLRDWLISRQRYWGTPIPMVHCEACGVVPVPEEELPVLLPDLKDVEDIRPKGKSPLEAHPEFYETTCPKCGGPAKRDTDTMDTFFDSSWYYLRYTDPHNDRLPFDPEKANAWMPVDQYIGGVEHAVLHLLYSRFFTKFLHDLGMVKVEEPFQGLFTQGMVLAWTDFGPVEVEGSVVRLPEPTRIRLEIPESALSLEDVRKMGAELRPHEDGTLHLWKPAVMSKSKGNGVMVGPFVKEQGADIARITILFAAPPENEMVWTEEGVQGAWRFLNRIYRRVAEDREALLETSGVFQAEALEGKDRELYGKLHETLKKVTEDLEALRFNTAIAALMEFLNALYEYRKDRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLFEAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLEVARAEALKVRNVRAHLEGKEVVKEIYVPGKILNLVVRG
  
Inhibitor
Name:
BDBM43823
Synonyms:
Kanamycin A, 1 | MLS000531200 | N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(1-piperidinylsulfonyl)benzamide | N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-piperidin-1-ylsulfonyl-benzamide | N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-piperidin-1-ylsulfonylbenzamide | N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-piperidinosulfonyl-benzamide | SMR000136178 | cid_1262699
Type:
Small organic molecule
Emp. Form.:
C20H22N2O5S
Mol. Mass.:
402.464
SMILES:
O=C(Nc1ccc2OCCOc2c1)c1cccc(c1)S(=O)(=O)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: