Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM44250
Substrate
n/a
Meas. Tech.
Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Activity against Muscarinic Panel
EC50
154±n/a nM
Citation
 PubChem, PC Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Activity against Muscarinic Panel PubChem Bioassay (2009)[AID] 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM44250
Synonyms:
4-[2-[(4-fluorobenzoyl)amino]ethylamino]piperidine-1-carboxylic acid ethyl ester;2,2,2-trifluoroacetic acid | 4-[2-[[(4-fluorophenyl)-oxomethyl]amino]ethylamino]-1-piperidinecarboxylic acid ethyl ester;2,2,2-trifluoroacetic acid | VU0359993 | cid_25010825 | ethyl 4-[2-[(4-fluorobenzoyl)amino]ethylamino]piperidine-1-carboxylate;2,2,2-trifluoroacetic acid | ethyl 4-[2-[(4-fluorophenyl)carbonylamino]ethylamino]piperidine-1-carboxylate;2,2,2-tris(fluoranyl)ethanoic acid
Type:
Small organic molecule
Emp. Form.:
C17H24FN3O3
Mol. Mass.:
337.3892
SMILES:
CCOC(=O)N1CCC(CC1)NCCNC(=O)c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: