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Target
Ephrin type-A receptor 4
Ligand
BDBM44524
Substrate
n/a
Meas. Tech.
Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists
IC50
8120±n/a nM
Citation
 PubChem, PC Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists PubChem Bioassay (2008)[AID] 
Target
Name:
Ephrin type-A receptor 4
Synonyms:
EPHA4_MOUSE | Eph receptor A4 | Epha4 | Sek | Sek1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
109812.17
Organism:
Mus musculus
Description:
gi_34328113
Residue:
986
Sequence:
MAGIFYFILFSFLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEASQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRESQFGKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEEQNGECQACKIGYYKALSTDASCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTRVSITDLLAHTNYTFEIWAVNGVSKYNPSPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGSESSRPNTALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHMSQDDLARIGITAITHQNKILSSVQAMRTQMQQMHGRMVPV
  
Inhibitor
Name:
BDBM44524
Synonyms:
2-(3,4-dimethoxybenzylidene)-5,6-diphenylimidazo[2,1-b][1,3]thiazol-3(2H)-one | 2-[(3,4-dimethoxyphenyl)methylidene]-5,6-diphenyl-3-imidazo[2,1-b]thiazolone | 2-[(3,4-dimethoxyphenyl)methylidene]-5,6-diphenyl-imidazo[2,1-b][1,3]thiazol-3-one | 2-[(3,4-dimethoxyphenyl)methylidene]-5,6-diphenylimidazo[2,1-b][1,3]thiazol-3-one | 5,6-diphenyl-2-veratrylidene-imidazo[2,1-b]thiazol-3-one | MLS000578034 | SMR000187219 | cid_2869441
Type:
Small organic molecule
Emp. Form.:
C26H20N2O3S
Mol. Mass.:
440.514
SMILES:
COc1ccc(C=c2sc3nc(c(-c4ccccc4)n3c2=O)-c2ccccc2)cc1OC
Structure:
Search PDB for entries with ligand similarity: