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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM45995
Substrate
n/a
Meas. Tech.
SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay
IC50
192±n/a nM
Citation
 PubChem, PC SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM45995
Synonyms:
3-(2,4-difluorophenyl)-1H-pyrazole-5-carboxylic acid methyl ester | MLS-0146287.0001 | cid_24178166 | methyl 3-(2,4-difluorophenyl)-1H-pyrazole-5-carboxylate | methyl 3-[2,4-bis(fluoranyl)phenyl]-1H-pyrazole-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C11H8F2N2O2
Mol. Mass.:
238.1902
SMILES:
COC(=O)c1cc(n[nH]1)-c1ccc(F)cc1F
Structure:
Search PDB for entries with ligand similarity: