Reaction Details Report a problem with these data
Target
Bcl-2-like protein 2
Ligand
BDBM32325
Substrate
n/a
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W.
EC50
1590±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-like protein 2
Synonyms:
Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Type:
Protein
Mol. Mass.:
20742.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK
  
Inhibitor
Name:
BDBM32325
Synonyms:
1-(3-chlorophenyl)-3-(2-pyridin-3-ylpyrimidin-4-yl)urea | 1-(3-chlorophenyl)-3-[2-(3-pyridinyl)-4-pyrimidinyl]urea | 1-(3-chlorophenyl)-3-[2-(3-pyridyl)pyrimidin-4-yl]urea | MLS000763594 | N-(3-chlorophenyl)-N'-[2-(3-pyridinyl)-4-pyrimidinyl]urea | SMR000337179 | cid_1488502
Type:
Small organic molecule
Emp. Form.:
C16H12ClN5O
Mol. Mass.:
325.752
SMILES:
Clc1cccc(NC(=O)Nc2ccnc(n2)-c2cccnc2)c1
Structure:
Search PDB for entries with ligand similarity: