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Target
Broad substrate specificity ATP-binding cassette transporter ABCG2
Ligand
BDBM47388
Substrate
n/a
Meas. Tech.
Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen
EC50
240±n/a nM
Citation
 PubChem, PC Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen PubChem Bioassay (2009)[AID] 
Target
Name:
Broad substrate specificity ATP-binding cassette transporter ABCG2
Synonyms:
ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter
Type:
Multi-pass membrane protein; monomer or homodimer; disulfide-linked
Mol. Mass.:
72329.48
Organism:
Homo sapiens (Human)
Description:
Q9UNQ0
Residue:
655
Sequence:
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
  
Inhibitor
Name:
BDBM47388
Synonyms:
3-chloranyl-N-[2-chloranyl-5-(trifluoromethyl)phenyl]-6-(3,5-dimethylpyrazol-1-yl)pyridine-2-carboxamide | 3-chloro-N-[2-chloro-5-(trifluoromethyl)phenyl]-6-(3,5-dimethyl-1-pyrazolyl)-2-pyridinecarboxamide | 3-chloro-N-[2-chloro-5-(trifluoromethyl)phenyl]-6-(3,5-dimethylpyrazol-1-yl)picolinamide | 3-chloro-N-[2-chloro-5-(trifluoromethyl)phenyl]-6-(3,5-dimethylpyrazol-1-yl)pyridine-2-carboxamide | UNM000011098501 | cid_2401094
Type:
Small organic molecule
Emp. Form.:
C18H13Cl2F3N4O
Mol. Mass.:
429.223
SMILES:
Cc1cc(C)n(n1)-c1ccc(Cl)c(n1)C(=O)Nc1cc(ccc1Cl)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: