Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetATP-sensitive inward rectifier potassium channel 1
LigandBDBM267010
Substrate/Competitorn/a
Meas. Tech.Thallium Flux Assay
IC50 120±n/a nM
Citation Biswas, DDing, FDong, SGu, XJiang, JPasternak, ASuzuki, TVacca, JXu, S Inhibitors of the renal outer medullary potassium channel US Patent US9718808 Publication Date 8/1/2017  Article
More Info.:Get all data from this article,  Assay Method
 
ATP-sensitive inward rectifier potassium channel 1
Name:ATP-sensitive inward rectifier potassium channel 1
Synonyms:Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:Enzyme Catalytic Domain
Mol. Mass.:44809.08
Organism:Homo sapiens (Human)
Description:gi_223460826
Residue:391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM267010
NameBDBM267010
Synonyms:US9718808, 139
TypeSmall organic molecule
Emp. Form.C25H32N8O4
Mol. Mass.508.5728
SMILESCN(C)C(=O)CN(Cc1ccc(nc1)-n1cnnn1)[C@H]1CC[C@]2(CCN(C3=C(C)C(=O)OC3)C2=O)CC1 |r,wU:19.20,wD:22.24,c:28,(-1.18,4.47,;.15,3.7,;1.48,4.47,;.15,2.16,;1.48,1.39,;-1.18,1.39,;-1.18,-.15,;-2.52,-.92,;-3.85,-.15,;-5.19,-.92,;-6.52,-.15,;-6.52,1.39,;-5.19,2.16,;-3.85,1.39,;-7.85,2.16,;-9.32,1.69,;-10.22,2.93,;-9.32,4.18,;-7.85,3.7,;.15,-.92,;1.48,-.15,;2.82,-.92,;2.82,-2.46,;2.82,-4,;4.28,-4.47,;5.19,-3.23,;6.52,-2.46,;7.42,-1.21,;6.65,.12,;8.89,-1.69,;10.22,-.92,;8.89,-3.23,;7.42,-3.7,;4.28,-1.98,;5.05,-.65,;1.48,-3.23,;.15,-2.46,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a