Reaction Details Report a problem with these data
Target
Estrogen receptor beta
Ligand
BDBM32135
Substrate
n/a
Meas. Tech.
Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation
IC50
4957.17±n/a nM
Citation
 PubChem, PC Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM32135
Synonyms:
4-[4-(3,4-dihydroxyphenyl)-3H-1,3-thiazol-2-ylidene]cyclohexa-2,5-dien-1-one | 4-[4-(3,4-dihydroxyphenyl)-3H-thiazol-2-ylidene]-1-cyclohexa-2,5-dienone | 4-[4-(3,4-dihydroxyphenyl)-4-thiazolin-2-ylidene]cyclohexa-2,5-dien-1-one | 4-[4-[3,4-bis(oxidanyl)phenyl]-3H-1,3-thiazol-2-ylidene]cyclohexa-2,5-dien-1-one | MLS000111214 | SMR000107140 | cid_5406370
Type:
Small organic molecule
Emp. Form.:
C15H11NO3S
Mol. Mass.:
285.318
SMILES:
Oc1ccc(cc1)-c1nc(cs1)-c1ccc(O)c(O)c1
Structure:
Search PDB for entries with ligand similarity: