Reaction Details Report a problem with these data
Target
Transcription factor p65
Ligand
BDBM49179
Substrate
n/a
Meas. Tech.
Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response
EC50
144±n/a nM
Citation
 PubChem, PC Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
Transcription factor p65
Synonyms:
NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:
Enzyme
Mol. Mass.:
60211.92
Organism:
Homo sapiens (Human)
Description:
Q04206
Residue:
551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM49179
Synonyms:
(3-Cyano-7-methoxy-quinolin-2-ylsulfanyl)-acetic acid ethyl ester | 2-[(3-cyano-7-methoxy-2-quinolinyl)thio]acetic acid ethyl ester | 2-[(3-cyano-7-methoxy-2-quinolyl)thio]acetic acid ethyl ester | MLS000074195 | SMR000001740 | cid_651177 | ethyl 2-(3-cyano-7-methoxy-quinolin-2-yl)sulfanylethanoate | ethyl 2-(3-cyano-7-methoxyquinolin-2-yl)sulfanylacetate
Type:
Small organic molecule
Emp. Form.:
C15H14N2O3S
Mol. Mass.:
302.348
SMILES:
CCOC(=O)CSc1nc2cc(OC)ccc2cc1C#N
Structure:
Search PDB for entries with ligand similarity: