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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50526
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
4830.692989±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50526
Synonyms:
2-thioxodihydropyrimidine-4,5,6(1H)-trione 5-[(3-nitro-1,1'-biphenyl-4-yl)hydrazone] | 5-[(2-nitro-4-phenyl-phenyl)hydrazinylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione | 5-[(2-nitro-4-phenyl-phenyl)hydrazono]-2-thioxo-hexahydropyrimidine-4,6-quinone | 5-[(2-nitro-4-phenylphenyl)hydrazinylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione | MLS000719967 | SMR000304496 | cid_6255619
Type:
Small organic molecule
Emp. Form.:
C16H11N5O4S
Mol. Mass.:
369.355
SMILES:
[O-][N+](=O)c1cc(ccc1[NH+]=N[c-]1c(=O)[nH]c(=S)[nH]c1=O)-c1ccccc1 |w:9.9|
Structure:
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