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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43477
Substrate
n/a
Meas. Tech.
E3 Ligase_Mutant_Dose Response
EC50
580±n/a nM
Citation
 PubChem, PC E3 Ligase_Mutant_Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43477
Synonyms:
1,4-Pentadien-3-one, 1,5-di-3-pyridyl- | 1,5-bis(3-pyridinyl)-3-penta-1,4-dienone | 1,5-bis(3-pyridyl)penta-1,4-dien-3-one | 1,5-dipyridin-3-ylpenta-1,4-dien-3-one | MLS000766145 | SMR000528628 | cid_288321
Type:
Small organic molecule
Emp. Form.:
C15H12N2O
Mol. Mass.:
236.2686
SMILES:
O=C(C=Cc1cccnc1)C=Cc1cccnc1
Structure:
Search PDB for entries with ligand similarity: