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Target
Mitogen-activated protein kinase kinase kinase kinase 2
Ligand
BDBM51843
Substrate
n/a
Meas. Tech.
Dose Response Confirmation Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Mutant
EC50
1770±n/a nM
Citation
 PubChem, PC Dose Response Confirmation Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Mutant PubChem Bioassay (2009)[AID] 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 2
Synonyms:
2.7.11.1 | B lymphocyte serine/threonine-protein kinase | GC kinase | GCK | Germinal center kinase | M4K2_HUMAN | MAP4K2 | MAPK/ERK kinase kinase kinase 2 | MEK kinase kinase 2 | MEKKK 2 | RAB8IP | Rab8-interacting protein
Type:
n/a
Mol. Mass.:
91551.35
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
820
Sequence:
MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPEDCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEPLSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY
  
Inhibitor
Name:
BDBM51843
Synonyms:
(2Z)-3-ethyl-2-[(1-ethyl-6,8-dimethyl-2-quinolin-1-iumyl)methylidene]-6-methyl-1,3-benzothiazole;iodide | (2Z)-3-ethyl-2-[(1-ethyl-6,8-dimethyl-quinolin-1-ium-2-yl)methylene]-6-methyl-1,3-benzothiazole;iodide | (2Z)-3-ethyl-2-[(1-ethyl-6,8-dimethyl-quinolin-1-ium-2-yl)methylidene]-6-methyl-1,3-benzothiazole;iodide | (2Z)-3-ethyl-2-[(1-ethyl-6,8-dimethylquinolin-1-ium-2-yl)methylidene]-6-methyl-1,3-benzothiazole;iodide | 1-ethyl-2-[(Z)-(3-ethyl-6-methyl-1,3-benzothiazol-2(3H)-ylidene)methyl]-6,8-dimethylquinolinium | MLS000727829 | SMR000306526 | cid_16192986
Type:
Small organic molecule
Emp. Form.:
C24H27N2S
Mol. Mass.:
375.549
SMILES:
CCN1\C(Sc2cc(C)ccc12)=C\c1ccc2cc(C)cc(C)c2[n+]1CC
Structure:
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