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TargetMitogen-activated protein kinase 2
LigandBDBM51875
Substrate/Competitorn/a
Meas. Tech.Dose Response Confirmation Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Mutant
EC50 2380±n/a nM
Citation PubChem, PC Dose Response Confirmation Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Mutant PubChem Bioassay(2009)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Mitogen-activated protein kinase 2
Name:Mitogen-activated protein kinase 2
Synonyms:2.7.11.1 | B lymphocyte serine/threonine-protein kinase | GC kinase | GCK | Germinal center kinase | MAP4K2 | MAPK/ERK kinase kinase kinase 2 | MEK kinase kinase 2 | MEKKK 2 | Mitogen-activated protein kinase kinase kinase kinase 2 | RAB8IP | Rab8-interacting protein
Type:n/a
Mol. Mass.:91551.35
Organism:Homo sapiens
Description:n/a
Residue:820
Sequence:
MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQ
EITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREA
LKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAP
EVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKT
RWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPE
DCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLG
KEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEP
LSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNG
CPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVL
LSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQ
CRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKE
LPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFE
RCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITD
ETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY
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BDBM51875
NameBDBM51875
Synonyms:2-amino-4-[4-(4-carbomethoxybenzyl)oxyphenyl]-6-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester | 2-amino-4-[4-[(4-methoxycarbonylphenyl)methoxy]phenyl]-6-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester | MLS001061287 | SMR000384995 | cid_4969429 | ethyl 2-amino-4-[4-[(4-methoxycarbonylphenyl)methoxy]phenyl]-6-phenyl-1,4-dihydropyrimidine-5-carboxylate | ethyl 2-azanyl-4-[4-[(4-methoxycarbonylphenyl)methoxy]phenyl]-6-phenyl-1,4-dihydropyrimidine-5-carboxylate
TypeSmall organic molecule
Emp. Form.C28H27N3O5
Mol. Mass.485.5311
SMILESCCOC(=O)C1C(N=C(N)N=C1c1ccccc1)c1ccc(OCc2ccc(cc2)C(=O)OC)cc1 |c:10,t:7|
Structure
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n/a
NameBDBM51875
Synonyms:2-amino-4-[4-(4-carbomethoxybenzyl)oxyphenyl]-6-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester | 2-amino-4-[4-[(4-methoxycarbonylphenyl)methoxy]phenyl]-6-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester | MLS001061287 | SMR000384995 | cid_4969429 | ethyl 2-amino-4-[4-[(4-methoxycarbonylphenyl)methoxy]phenyl]-6-phenyl-1,4-dihydropyrimidine-5-carboxylate | ethyl 2-azanyl-4-[4-[(4-methoxycarbonylphenyl)methoxy]phenyl]-6-phenyl-1,4-dihydropyrimidine-5-carboxylate
TypeSmall organic molecule
Emp. Form.C28H27N3O5
Mol. Mass.485.5311
SMILESCCOC(=O)C1C(N=C(N)N=C1c1ccccc1)c1ccc(OCc2ccc(cc2)C(=O)OC)cc1 |c:10,t:7|
Structure
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