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Reaction Details
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TargetMPI protein
LigandBDBM34792
Substrate/Competitorn/a
Meas. Tech.HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50 50000±n/a nM
Citation PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay(2009)[AID]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
MPI protein
Name:Mannose-6-phosphate isomerase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:46651.35
Organism:Homo sapiens (Human)
Description:ChEMBL_1448919
Residue:423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM34792
NameBDBM34792
Synonyms:(1Z)-6-bromanyl-1-[[(5-methyl-1,2-oxazol-3-yl)amino]methylidene]naphthalen-2-one | (1Z)-6-bromo-1-[[(5-methyl-1,2-oxazol-3-yl)amino]methylidene]naphthalen-2-one | (1Z)-6-bromo-1-[[(5-methyl-3-isoxazolyl)amino]methylidene]-2-naphthalenone | (1Z)-6-bromo-1-[[(5-methylisoxazol-3-yl)amino]methylene]naphthalen-2-one | 6-bromo-1-{[(5-methyl-3-isoxazolyl)imino]methyl}-2-naphthol | MLS000705204 | SMR000230543 | cid_5454386
TypeSmall organic molecule
Emp. Form.C15H11BrN2O2
Mol. Mass.331.164
SMILESCc1cc(N=Cc2c(O)ccc3cc(Br)ccc23)no1 |w:4.3|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a