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Target
Apoptosis regulator Bcl-2
Ligand
BDBM33057
Substrate
n/a
Meas. Tech.
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
1900±n/a nM
Citation
 PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2009)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM33057
Synonyms:
6-methyl-2-(1-naphthalenyl)-5-benzotriazolamine | 6-methyl-2-(1-naphthyl)-2H-1,2,3-benzotriazol-5-amine | 6-methyl-2-naphthalen-1-yl-benzotriazol-5-amine | 6-methyl-2-naphthalen-1-ylbenzotriazol-5-amine | MLS000064228 | SMR000076237 | [6-methyl-2-(1-naphthyl)benzotriazol-5-yl]amine | cid_938026
Type:
Small organic molecule
Emp. Form.:
C17H14N4
Mol. Mass.:
274.3199
SMILES:
Cc1cc2nn(nc2cc1N)-c1cccc2ccccc12
Structure:
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