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Target
Apoptosis regulator Bcl-2
Ligand
BDBM33196
Substrate
n/a
Meas. Tech.
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
12100±n/a nM
Citation
 PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2009)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM33196
Synonyms:
MLS001013472 | N-[1,4-diketo-3-(o-anisidino)-2-naphthyl]acetamide | N-[3-(2-methoxyanilino)-1,4-dioxo-2-naphthalenyl]acetamide | N-[3-(2-methoxyanilino)-1,4-dioxonaphthalen-2-yl]acetamide | N-[3-[(2-methoxyphenyl)amino]-1,4-bis(oxidanylidene)naphthalen-2-yl]ethanamide | SMR000353464 | cid_284927
Type:
Small organic molecule
Emp. Form.:
C19H16N2O4
Mol. Mass.:
336.3413
SMILES:
COc1ccccc1NC1=C(NC(C)=O)C(=O)c2ccccc2C1=O |c:10|
Structure:
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