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Target
Bcl-2-like protein 10 [11-204]
Ligand
BDBM33173
Substrate
n/a
Meas. Tech.
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B
EC50
2900±n/a nM
Citation
 PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 10 [11-204]
Synonyms:
Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH). | B2L10_HUMAN | BCL-B | BCL2L10 | BCLB | BOO | DIVA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21981.77
Organism:
Homo sapiens (Human)
Description:
gi_23396469
Residue:
194
Sequence:
MADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL
  
Inhibitor
Name:
BDBM33173
Synonyms:
(5E)-5-(2-furanylmethylidene)-3-phenyl-2-sulfanylidene-4-imidazolidinone | (5E)-5-(2-furfurylidene)-3-phenyl-2-thioxo-4-imidazolidinone | (5E)-5-(furan-2-ylmethylidene)-3-phenyl-2-sulfanylidene-imidazolidin-4-one | (5E)-5-(furan-2-ylmethylidene)-3-phenyl-2-sulfanylideneimidazolidin-4-one | MLS000693194 | SMR000284616 | cid_5751662
Type:
Small organic molecule
Emp. Form.:
C14H10N2O2S
Mol. Mass.:
270.306
SMILES:
O=C1N(C(=S)NC1=Cc1ccco1)c1ccccc1 |w:7.8|
Structure:
Search PDB for entries with ligand similarity: