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Target
Streptokinase A
Ligand
BDBM57357
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
150000±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM57357
Synonyms:
(3E)-2-amino-3-[(3-methoxyphenyl)hydrazinylidene]-5-phenyl-7-pyrazolo[1,5-a]pyrimidinone | (3E)-2-amino-3-[(3-methoxyphenyl)hydrazinylidene]-5-phenylpyrazolo[1,5-a]pyrimidin-7-one | (3E)-2-amino-3-[(3-methoxyphenyl)hydrazono]-5-phenyl-pyrazolo[1,5-a]pyrimidin-7-one | (3E)-2-azanyl-3-[(3-methoxyphenyl)hydrazinylidene]-5-phenyl-pyrazolo[1,5-a]pyrimidin-7-one | 2-amino-3-[(3-methoxyphenyl)diazenyl]-5-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one | MLS000540219 | SMR000162512 | cid_11958755
Type:
Small organic molecule
Emp. Form.:
C19H16N6O2
Mol. Mass.:
360.3693
SMILES:
COc1cccc(c1)N=Nc1c(N)[nH]n2c1nc(cc2=O)-c1ccccc1 |w:9.10|
Structure:
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