Reaction Details Report a problem with these data
Target
Streptokinase A
Ligand
BDBM58058
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
150000±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM58058
Synonyms:
2-methyl-3-[[(E)-(1-oxidanylidenenaphthalen-2-ylidene)methyl]amino]quinazolin-4-one | 2-methyl-3-[[(E)-(1-oxo-2-naphthalenylidene)methyl]amino]-4-quinazolinone | 2-methyl-3-[[(E)-(1-oxonaphthalen-2-ylidene)methyl]amino]quinazolin-4-one | 3-[[(E)-(1-keto-2-naphthylidene)methyl]amino]-2-methyl-quinazolin-4-one | 3-{[1-(1-Hydroxy-naphthalen-2-yl)-meth-(E)-ylidene]-amino}-2-methyl-3H-quinazolin-4-one | MLS000777338 | SMR000413723 | cid_5423268
Type:
Small organic molecule
Emp. Form.:
C20H15N3O2
Mol. Mass.:
329.352
SMILES:
Cc1nc2ccccc2c(=O)n1N=Cc1ccc2ccccc2c1O |w:12.13|
Structure:
Search PDB for entries with ligand similarity: