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Target
Streptokinase A
Ligand
BDBM58631
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
31035±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM58631
Synonyms:
1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(3-chloro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-5-[(4-methyl-1-piperidinyl)methyl]-4-triazolecarbohydrazide | 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(3-chloro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-5-[(4-methylpiperidin-1-yl)methyl]triazole-4-carbohydrazide | 1-(4-aminofurazan-3-yl)-N'-[(E)-(3-chloro-6-keto-cyclohexa-2,4-dien-1-ylidene)methyl]-5-[(4-methylpiperidino)methyl]triazole-4-carbohydrazide | 1-(4-azanyl-1,2,5-oxadiazol-3-yl)-N'-[(E)-(3-chloranyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]-5-[(4-methylpiperidin-1-yl)methyl]-1,2,3-triazole-4-carbohydrazide | MLS000923842 | SMR000620334 | cid_6295079
Type:
Small organic molecule
Emp. Form.:
C19H22ClN9O3
Mol. Mass.:
459.889
SMILES:
CC1CCN(Cc2c(nnn2-c2nonc2N)C(=O)NN=Cc2cc(Cl)ccc2O)CC1 |w:20.21|
Structure:
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