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Target
G1/S-specific cyclin-E1
Ligand
BDBM50277583
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
IC50
1.0e+3±n/a nM
Citation
 McInnes, C; Wang, S; Anderson, S; O'Boyle, J; Jackson, W; Kontopidis, G; Meades, C; Mezna, M; Thomas, M; Wood, G; Lane, DP; Fischer, PM Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. Chem Biol 11:525-34 (2004) [PubMed]  Article 
Target
Name:
G1/S-specific cyclin-E1
Synonyms:
CCNE | CCNE1 | CCNE1_HUMAN
Type:
Enzyme Subunit
Mol. Mass.:
47073.17
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
410
Sequence:
MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
  
Inhibitor
Name:
BDBM50277583
Synonyms:
2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine, 5 | 4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine | Aminopyrimidine, 9 | CHEMBL482967 | CYC-116
Type:
Small organic molecule
Emp. Form.:
C18H20N6OS
Mol. Mass.:
368.456
SMILES:
Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Structure:
Search PDB for entries with ligand similarity: