Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase XIAP
Ligand
BDBM59382
Substrate
n/a
Meas. Tech.
Chemical Antagonists IAP-family anti-apoptotic proteins
IC50
100000±n/a nM
Citation
 PubChem, PC Chemical Antagonists IAP-family anti-apoptotic proteins PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase XIAP
Synonyms:
API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
56685.27
Organism:
Homo sapiens (Human)
Description:
P98170
Residue:
497
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
  
Inhibitor
Name:
BDBM59382
Synonyms:
1-(2,5-dimethylthiophen-3-yl)sulfonyl-4-(phenylmethyl)piperazine;hydrochloride | 1-[(2,5-dimethyl-3-thiophenyl)sulfonyl]-4-(phenylmethyl)piperazine;hydrochloride | 1-benzyl-4-(2,5-dimethylthiophen-3-yl)sulfonylpiperazine;hydrochloride | 1-benzyl-4-[(2,5-dimethyl-3-thienyl)sulfonyl]piperazine;hydrochloride | 1-benzyl-4-[(2,5-dimethylthien-3-yl)sulfonyl]piperazine | MLS000120451 | SMR000102064 | cid_6603587
Type:
Small organic molecule
Emp. Form.:
C17H22N2O2S2
Mol. Mass.:
350.499
SMILES:
Cc1cc(c(C)s1)S(=O)(=O)N1CCN(Cc2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: