Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61318
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
60805±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61318
Synonyms:
MLS000807104 | N-(2-chlorophenyl)-2-[[2-(2-furfurylcarbamoylamino)-2-keto-ethyl]-methyl-amino]acetamide | N-(2-chlorophenyl)-2-[[2-(furan-2-ylmethylcarbamoylamino)-2-oxidanylidene-ethyl]-methyl-amino]ethanamide | N-(2-chlorophenyl)-2-[[2-(furan-2-ylmethylcarbamoylamino)-2-oxoethyl]-methylamino]acetamide | N-(2-chlorophenyl)-2-[[2-[[(2-furanylmethylamino)-oxomethyl]amino]-2-oxoethyl]-methylamino]acetamide | SMR000376203 | cid_2698464
Type:
Small organic molecule
Emp. Form.:
C17H19ClN4O4
Mol. Mass.:
378.81
SMILES:
CN(CC(=O)NC(=O)NCc1ccco1)CC(=O)Nc1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: