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Target
Heat shock factor protein 1
Ligand
BDBM56539
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM56539
Synonyms:
MLS000578482 | N-[3-[(E)-3-(4-methylphenyl)-1-oxoprop-2-enyl]phenyl]acetamide | N-[3-[(E)-3-(4-methylphenyl)prop-2-enoyl]phenyl]acetamide | N-[3-[(E)-3-(4-methylphenyl)prop-2-enoyl]phenyl]ethanamide | N-[3-[(E)-3-(p-tolyl)acryloyl]phenyl]acetamide | N-{3-[3-(4-methylphenyl)acryloyl]phenyl}acetamide | SMR000198482 | cid_5738116
Type:
Small organic molecule
Emp. Form.:
C18H17NO2
Mol. Mass.:
279.3331
SMILES:
CC(=O)Nc1cccc(c1)C(=O)\C=C\c1ccc(C)cc1
Structure:
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