Reaction Details Report a problem with these data
Target
General amino acid permease AGP1
Ligand
BDBM66025
Substrate
n/a
Meas. Tech.
Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically AGP1 based on MLPCN hits
EC50
4608±n/a nM
Citation
 PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically AGP1 based on MLPCN hits PubChem Bioassay (2010)[AID] 
Target
Name:
General amino acid permease AGP1
Synonyms:
AGP1 | AGP1_YEAST | Agp1p
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69674.09
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_85666113
Residue:
633
Sequence:
MSSSKSLYELKDLKNSSTEIHATGQDNEIEYFETGSNDRPSSQPHLGYEQHNTSAVRRFFDSFKRADQGPQDEVEATQMNDLTSAISPSSRQAQELEKNESSDNIGANTGHKSDSLKKTIQPRHVLMIALGTGIGTGLLVGNGTALVHAGPAGLLIGYAIMGSILYCIIQACGEMALVYSNLTGGYNAYPSFLVDDGFGFAVAWVYCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVIIFYVLVITINIFGARGYAEAEFFFNCCKILMMTGFFILGIIIDVGGAGNDGFIGGKYWHDPGAFNGKHAIDRFKGVAATLVTAAFAFGGSEFIAITTAEQSNPRKAIPGAAKQMIYRILFLFLATIILLGFLVPYNSDQLLGSTGGGTKASPYVIAVASHGVRVVPHFINAVILLSVLSMANSSFYSSARLFLTLSEQGYAPKVFSYIDRAGRPLIAMGVSALFAVIAFCAASPKEEQVFTWLLAISGLSQLFTWTAICLSHLRFRRAMKVQGRSLGELGFKSQTGVWGSAYACIMMILILIAQFWVAIAPIGEGKLDAQAFFENYLAMPILIALYVGYKVWHKDWKLFIRADKIDLDSHRQIFDEELIKQEDEEYRERLRNGPYWKRVVAFWC
  
Inhibitor
Name:
BDBM66025
Synonyms:
1-(2-furanylmethyl)-2-[(4-methyl-1-piperazinyl)methylideneamino]-4,5-diphenyl-3-pyrrolecarbonitrile | 1-(2-furfuryl)-2-[(4-methylpiperazino)methyleneamino]-4,5-diphenyl-pyrrole-3-carbonitrile | 1-(furan-2-ylmethyl)-2-[(4-methylpiperazin-1-yl)methylideneamino]-4,5-diphenyl-pyrrole-3-carbonitrile | 1-(furan-2-ylmethyl)-2-[(4-methylpiperazin-1-yl)methylideneamino]-4,5-diphenylpyrrole-3-carbonitrile | 1-Furan-2-ylmethyl-2-{[1-(4-methyl-piperazin-1-yl)-meth-(E)-ylidene]-amino}-4,5-diphenyl-1H-pyrrole-3-c arbonitrile | MLS000556474 | SMR000147791 | cid_1531603
Type:
Small organic molecule
Emp. Form.:
C28H27N5O
Mol. Mass.:
449.5469
SMILES:
CN1CCN(CC1)C=Nc1c(C#N)c(c(-c2ccccc2)n1Cc1ccco1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: