Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM59833
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)
IC50
1492±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM59833
Synonyms:
2-(8-chloro-4-keto-2-thioxo-1H-benzofuro[3,2-d]pyrimidin-3-yl)acetic acid ethyl ester | 2-(8-chloro-4-oxo-2-sulfanylidene-1H-benzofuro[3,2-d]pyrimidin-3-yl)acetic acid ethyl ester | MLS000519963 | SMR000130378 | cid_9551120 | ethyl 2-(8-chloranyl-4-oxidanylidene-2-sulfanylidene-1H-[1]benzofuro[3,2-d]pyrimidin-3-yl)ethanoate | ethyl 2-(8-chloro-4-oxo-2-sulfanylidene-1H-[1]benzofuro[3,2-d]pyrimidin-3-yl)acetate
Type:
Small organic molecule
Emp. Form.:
C14H11ClN2O4S
Mol. Mass.:
338.766
SMILES:
CCOC(=O)Cn1c(=S)[nH]c2c3cc(Cl)ccc3oc2c1=O
Structure:
Search PDB for entries with ligand similarity: