Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM50925
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)
IC50
>1476±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM50925
Synonyms:
5-methyl-4-phenyl-cyclopenta[c]quinolizine-1,2-dicarboxylic acid dimethyl ester | 5-methyl-4-phenylcyclopenta[c]quinolizine-1,2-dicarboxylic acid dimethyl ester | MLS000537611 | SMR000161420 | cid_990753 | dimethyl 5-methyl-4-phenyl-cyclopenta[c]quinolizine-1,2-dicarboxylate | dimethyl 5-methyl-4-phenylcyclopenta[c]quinolizine-1,2-dicarboxylate
Type:
Small organic molecule
Emp. Form.:
C23H19NO4
Mol. Mass.:
373.4013
SMILES:
COC(=O)c1cc2c(-c3ccccc3)c(C)c3ccccn3c2c1C(=O)OC
Structure:
Search PDB for entries with ligand similarity: