Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM41042
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)
IC50
177.87±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM41042
Synonyms:
7-(4-fluorophenyl)-5-(4-methylphenyl)-4-pyrido[2,3-d]pyrimidinamine | 7-(4-fluorophenyl)-5-(4-methylphenyl)pyrido[2,3-d]pyrimidin-4-amine | 7-(4-fluorophenyl)-5-(4-methylphenyl)pyrido[2,3-d]pyrimidin-4-ylamine | MLS000538794 | SMR000161339 | [7-(4-fluorophenyl)-5-(p-tolyl)pyrido[2,3-d]pyrimidin-4-yl]amine | cid_1234281
Type:
Small organic molecule
Emp. Form.:
C20H15FN4
Mol. Mass.:
330.3583
SMILES:
Cc1ccc(cc1)-c1cc(nc2ncnc(N)c12)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: