Target
Serine/threonine-protein kinase 33
Ligand
BDBM67696
Substrate
n/a
Meas. Tech.
Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity
EC50
8379±n/a nM
Citation
 PubChem, PC Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity PubChem Bioassay (2010)[AID] 
Target
Name:
Serine/threonine-protein kinase 33
Synonyms:
STK33 | STK33_HUMAN | Serine/threonine-protein kinase 33
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57833.21
Organism:
Homo sapiens (Human)
Description:
gi_23943882
Residue:
514
Sequence:
MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
  
Inhibitor
Name:
BDBM67696
Synonyms:
3-methoxy-4-[[5-methyl-9-(4-oxidanylcyclohexyl)-6-oxidanylidene-7,8-dihydropyrimido[4,5-b][1,4]diazepin-2-yl]amino]-N-(1-methylpiperidin-4-yl)benzamide | 4-[[9-(4-hydroxycyclohexyl)-5-methyl-6-oxo-7,8-dihydropyrimido[4,5-b][1,4]diazepin-2-yl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide | 4-[[9-(4-hydroxycyclohexyl)-5-methyl-6-oxo-7,8-dihydropyrimido[4,5-b][1,4]diazepin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | 4-[[9-(4-hydroxycyclohexyl)-6-keto-5-methyl-7,8-dihydropyrimido[4,5-b][1,4]diazepin-2-yl]amino]-3-methoxy-N-(1-methyl-4-piperidyl)benzamide | MLS002232305 | SMR001307859 | cid_42601363
Type:
Small organic molecule
Emp. Form.:
C28H39N7O4
Mol. Mass.:
537.6538
SMILES:
COc1cc(ccc1Nc1ncc2N(C)C(=O)CCN(C3CCC(O)CC3)c2n1)C(=O)NC1CCN(C)CC1 |(10.87,-5.35,;10.86,-3.81,;12.19,-3.03,;13.53,-3.8,;14.86,-3.02,;14.85,-1.48,;13.52,-.72,;12.19,-1.49,;10.85,-.73,;9.52,-1.5,;9.52,-3.11,;8.12,-3.9,;6.75,-3.07,;5.54,-4.03,;5.88,-5.54,;4.04,-3.69,;3.08,-4.9,;3.37,-2.3,;4.04,-.92,;5.54,-.57,;5.88,.93,;7.36,1.38,;7.7,2.88,;6.57,3.93,;6.91,5.43,;5.1,3.48,;4.76,1.97,;6.75,-1.53,;8.12,-.71,;16.2,-3.79,;16.2,-5.33,;17.53,-3.01,;18.86,-3.78,;18.87,-5.32,;20.21,-6.08,;21.54,-5.31,;22.87,-6.07,;21.53,-3.77,;20.19,-3,)|
Structure:
Search PDB for entries with ligand similarity: