Reaction Details Report a problem with these data
Target
Serine/threonine-protein phosphatase
Ligand
BDBM64576
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin
EC50
5989±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin PubChem Bioassay (2010)[AID] 
Target
Name:
Serine/threonine-protein phosphatase
Synonyms:
calcineurin A1, putative | calmodulin-binding protein 1, putative | serine/threonine-protein phosphatase 2B catalytic subunit A1, putative
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69558.03
Organism:
Candida dubliniensis CD36
Description:
gi_223640082
Residue:
607
Sequence:
MSGNTVQRNTEQINNALNAIQHRRTTTGNDLNHTNQRIISQNSINDKDYTIYITDDGEKYSTVERAVKSVDPPVTFKPKDEQVFLSNGKPNHQFLKQHFIHEGRLHEHQAIQILKQATHLLSKESNLLNVPAPVTICGDVHGQYYDLMKLFEVGGDPATTKYLFLGDYVDRGSFSIECLLYLYSLKINYPDTFWMLRGNHECRHLTEYFTFKNECLHKYSEQLYEECLVSFNALPLAAIMNEQFFCVHGGLSPQLTSLDSLRKLHRFREPPTKGLMCDLLWADPIEEYDEDNIDQEYVTNVVRGCSFAFTYKAACKFLDKTKLLSVIRAHEAQNAGYRMYKRTKTMGFPSLLTMFSAPNYLDSYNNKAAVLKYENNVMNIRQFNASPHPYWLPHFMDVFTWSLPFVGEKVTDMLVSILNVCTEEELDEDLPFSESEIGVATKTTKTTTPVSPVSPKAHPPSTRITSPYKSTKLVESDNNPNTNNDDSEMTLEEKKQALRNKIIAIGKMSRMFQVLREEQENVAHLKELNRGSLPKGSLLHGVDGLKNTINSFEEAKAADRINEALPPSPEDIQRLKQEKNTRIRQQIENQEMSGPVFQRLIRRLSQS
  
Inhibitor
Name:
BDBM64576
Synonyms:
(3Z)-5-ethyl-3-(2-oxidanylidene-2-thiophen-2-yl-ethylidene)-1H-indol-2-one | (3Z)-5-ethyl-3-(2-oxo-2-thiophen-2-ylethylidene)-1H-indol-2-one | (3Z)-5-ethyl-3-[2-keto-2-(2-thienyl)ethylidene]oxindole | 5-ethyl-3-[2-oxo-2-(2-thienyl)ethylidene]-1,3-dihydro-2H-indol-2-one | MLS000536892 | SMR000143539 | cid_977927
Type:
Small organic molecule
Emp. Form.:
C16H13NO2S
Mol. Mass.:
283.345
SMILES:
CCc1ccc2NC(=O)\C(=C/C(=O)c3cccs3)c2c1
Structure:
Search PDB for entries with ligand similarity: