Reaction Details Report a problem with these data
Target
Glycogen synthase kinase-3 beta
Ligand
BDBM68349
Substrate
n/a
Meas. Tech.
Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity
EC50
>300000±n/a nM
Citation
 PubChem, PC Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity PubChem Bioassay (2010)[AID] 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM68349
Synonyms:
4-[(4-Benzothiazol-2-yl-piperazin-1-yl)-(1-tert-butyl-1H-tetrazol-5-yl)-methyl]-2-methoxy-phenol | 4-[[4-(1,3-benzothiazol-2-yl)-1-piperazinyl]-(1-tert-butyl-5-tetrazolyl)methyl]-2-methoxyphenol | 4-[[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-(1-tert-butyl-1,2,3,4-tetrazol-5-yl)methyl]-2-methoxy-phenol | 4-[[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-(1-tert-butyltetrazol-5-yl)methyl]-2-methoxyphenol | 4-[[4-(1,3-benzothiazol-2-yl)piperazino]-(1-tert-butyltetrazol-5-yl)methyl]-2-methoxy-phenol | MLS000027473 | SMR000004488 | cid_646829
Type:
Small organic molecule
Emp. Form.:
C24H29N7O2S
Mol. Mass.:
479.598
SMILES:
COc1cc(ccc1O)C(N1CCN(CC1)c1nc2ccccc2s1)c1nnnn1C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: