Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM72397
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
11650±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM72397
Synonyms:
MLS000663866 | N-[3-[(E)-3-(4-fluorophenyl)-1-oxoprop-2-enyl]phenyl]propanamide | N-[3-[(E)-3-(4-fluorophenyl)acryloyl]phenyl]propionamide | N-[3-[(E)-3-(4-fluorophenyl)prop-2-enoyl]phenyl]propanamide | N-{3-[3-(4-fluorophenyl)acryloyl]phenyl}propanamide | SMR000292397 | cid_5738104
Type:
Small organic molecule
Emp. Form.:
C18H16FNO2
Mol. Mass.:
297.3235
SMILES:
CCC(=O)Nc1cccc(c1)C(=O)\C=C\c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: