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Target
Furin
Ligand
BDBM75778
Substrate
n/a
Meas. Tech.
High throughput fluorescence intensity-based biochemical assay to screen for small molecule inhibitors of Furin:Concentration-response Confirmation Assays
IC50
>50000±n/a nM
Citation
 PubChem, PC High throughput fluorescence intensity-based biochemical assay to screen for small molecule inhibitors of Furin:Concentration-response Confirmation Assays PubChem Bioassay (2010)[AID] 
Target
Name:
Furin
Synonyms:
FUR | FURIN | FURIN_HUMAN | Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA | PACE | PCSK3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
86676.01
Organism:
Homo sapiens (Human)
Description:
P09958
Residue:
794
Sequence:
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
  
Inhibitor
Name:
BDBM75778
Synonyms:
(4-Dimethylamino-phenyl)-[(4-dimethylamino-phenyl)-phenylamino-methyl]-phosphinic acid propyl ester | 4-[[[4-(dimethylamino)phenyl]-propoxy-phosphoryl]-phenylazanyl-methyl]-N,N-dimethyl-aniline | 4-[anilino-[[4-(dimethylamino)phenyl]-propoxyphosphoryl]methyl]-N,N-dimethylaniline | MLS000331499 | SMR000220941 | [4-[[anilino-[4-(dimethylamino)phenyl]methyl]-propoxy-phosphoryl]phenyl]-dimethyl-amine | cid_3835082
Type:
Small organic molecule
Emp. Form.:
C26H34N3O2P
Mol. Mass.:
451.5408
SMILES:
CCCOP(=O)(C(Nc1ccccc1)c1ccc(cc1)N(C)C)c1ccc(cc1)N(C)C
Structure:
Search PDB for entries with ligand similarity: