Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM55196
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
2520±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM55196
Synonyms:
2-(2,4-Dimethyl-5-oxo-4,5-dihydro-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-6-yl)-N-phenethyl-acetamide | 2-(2,4-dimethyl-5-oxidanylidene-thieno[3,4]pyrrolo[1,3-d]pyridazin-6-yl)-N-(2-phenylethyl)ethanamide | 2-(2,4-dimethyl-5-oxo-6-thieno[3,4]pyrrolo[1,3-d]pyridazinyl)-N-(2-phenylethyl)acetamide | 2-(2,4-dimethyl-5-oxothieno[3,4]pyrrolo[1,3-d]pyridazin-6-yl)-N-(2-phenylethyl)acetamide | 2-(5-keto-2,4-dimethyl-thieno[3,4]pyrrolo[1,3-d]pyridazin-6-yl)-N-phenethyl-acetamide | MLS000076138 | SMR000000722 | cid_650226
Type:
Small organic molecule
Emp. Form.:
C20H20N4O2S
Mol. Mass.:
380.463
SMILES:
Cc1cc2n(C)c3c(cnn(CC(=O)NCCc4ccccc4)c3=O)c2s1
Structure:
Search PDB for entries with ligand similarity: