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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM76222
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay
IC50
1870±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM76222
Synonyms:
MLS001072174 | N-[3-(3-chlorophenyl)phenyl]-1-[(1-ethyl-3,5-dimethyl-4-pyrazolyl)methyl]-4-piperidinecarboxamide | N-[3-(3-chlorophenyl)phenyl]-1-[(1-ethyl-3,5-dimethyl-pyrazol-4-yl)methyl]isonipecotamide | N-[3-(3-chlorophenyl)phenyl]-1-[(1-ethyl-3,5-dimethyl-pyrazol-4-yl)methyl]piperidine-4-carboxamide | N-[3-(3-chlorophenyl)phenyl]-1-[(1-ethyl-3,5-dimethylpyrazol-4-yl)methyl]piperidine-4-carboxamide | SMR000654370 | cid_24816640
Type:
Small organic molecule
Emp. Form.:
C26H31ClN4O
Mol. Mass.:
451.004
SMILES:
CCn1nc(C)c(CN2CCC(CC2)C(=O)Nc2cccc(c2)-c2cccc(Cl)c2)c1C
Structure:
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