Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM76100
Substrate
n/a
Meas. Tech.
Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM76100
Synonyms:
3-[[[1-(1-cyclohexyl-1,2,3,4-tetrazol-5-yl)-2-methyl-propyl]-(2-hydroxyethyl)amino]methyl]-6-ethoxy-1H-quinolin-2-one | 3-[[[1-(1-cyclohexyl-5-tetrazolyl)-2-methylpropyl]-(2-hydroxyethyl)amino]methyl]-6-ethoxy-1H-quinolin-2-one | 3-[[[1-(1-cyclohexyltetrazol-5-yl)-2-methyl-propyl]-(2-hydroxyethyl)amino]methyl]-6-ethoxy-carbostyril | 3-[[[1-(1-cyclohexyltetrazol-5-yl)-2-methylpropyl]-(2-hydroxyethyl)amino]methyl]-6-ethoxy-1H-quinolin-2-one | 3-{[[1-(1-Cyclohexyl-1H-tetrazol-5-yl)-2-methyl-propyl]-(2-hydroxy-ethyl)-amino]-methyl}-6-ethoxy-1H-quinolin-2-one | MLS000072982 | SMR000004541 | cid_646961
Type:
Small organic molecule
Emp. Form.:
C25H36N6O3
Mol. Mass.:
468.5917
SMILES:
CCOc1ccc2[nH]c(=O)c(CN(CCO)C(C(C)C)c3nnnn3C3CCCCC3)cc2c1
Structure:
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