Reaction Details Report a problem with these data
Target
Alkaline phosphatase, germ cell type
Ligand
BDBM75627
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase
EC50
11000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, germ cell type
Synonyms:
ALPG | ALPPL | ALPPL2 | Alkaline phosphatase placental-like | PPBN_HUMAN | placental-like alkaline phosphatase preproprotein
Type:
PROTEIN
Mol. Mass.:
57374.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_29964
Residue:
532
Sequence:
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
  
Inhibitor
Name:
BDBM75627
Synonyms:
4-Bromo-2H-pyrazole-3-carboxylic acid [1-(2-hydroxy-naphthalen-1-yl)-meth-(E)-ylidene]-hydrazide | 4-bromanyl-N'-[(Z)-(2-oxidanylidenenaphthalen-1-ylidene)methyl]-1H-pyrazole-5-carbohydrazide | 4-bromo-N'-[(Z)-(2-keto-1-naphthylidene)methyl]-1H-pyrazole-5-carbohydrazide | 4-bromo-N'-[(Z)-(2-oxo-1-naphthalenylidene)methyl]-1H-pyrazole-5-carbohydrazide | 4-bromo-N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]-1H-pyrazole-5-carbohydrazide | MLS000588004 | SMR000211991 | cid_6506002
Type:
Small organic molecule
Emp. Form.:
C15H11BrN4O2
Mol. Mass.:
359.177
SMILES:
Oc1ccc2ccccc2c1C=NNC(=O)c1[nH]ncc1Br |w:12.14|
Structure:
Search PDB for entries with ligand similarity: