Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM78441
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
5540±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM78441
Synonyms:
6-bromanyl-1-[(3-fluorophenyl)methyl]-2,2-bis(oxidanylidene)-2,1-benzothiazin-4-one | 6-bromo-1-(3-fluorobenzyl)-2,2-diketo-2,1-benzothiazin-4-one | 6-bromo-1-[(3-fluorophenyl)methyl]-2,2-dioxo-2,1-benzothiazin-4-one | MLS002240618 | SMR001308285 | cid_42628492
Type:
Small organic molecule
Emp. Form.:
C15H11BrFNO3S
Mol. Mass.:
384.22
SMILES:
Fc1cccc(CN2c3ccc(Br)cc3C(=O)CS2(=O)=O)c1
Structure:
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