Reaction Details Report a problem with these data
Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM78723
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay
IC50
>20000±0 nM
Citation
PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay PubChem Bioassay (2011)[AID]
More Info.:
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
Inhibitor
Name:
BDBM78723
Synonyms:
5-[2-hydroxy-3-(3-hydroxypropylamino)propoxy]-2-methyl-1-(4-methylphenyl)-3-indolecarboxylic acid ethyl ester;hydrochloride | 5-[2-hydroxy-3-(3-hydroxypropylamino)propoxy]-2-methyl-1-(p-tolyl)indole-3-carboxylic acid ethyl ester;hydrochloride | MLS000727513 | SMR000306210 | cid_16188856 | ethyl 2-methyl-1-(4-methylphenyl)-5-[2-oxidanyl-3-(3-oxidanylpropylamino)propoxy]indole-3-carboxylate;hydrochloride | ethyl 5-[2-hydroxy-3-(3-hydroxypropylamino)propoxy]-2-methyl-1-(4-methylphenyl)indole-3-carboxylate;hydrochloride | ethyl 5-{2-hydroxy-3-[(3-hydroxypropyl)amino]propoxy}-2-methyl-1-(4-methylphenyl)-1H-indole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C25H32N2O5
Mol. Mass.:
440.532
SMILES:
CCOC(=O)c1c(C)n(-c2ccc(C)cc2)c2ccc(OCC(O)CNCCCO)cc12