Reaction Details Report a problem with these data
Target
Caspase-7
Ligand
BDBM79431
Substrate
n/a
Meas. Tech.
Dose response assay for dual activators of procaspase-3 and procaspase-7: Absorbance-based biochemical high throughput screening assay to identify activators of procaspase-7
EC50
>85236±n/a nM
Citation
 PubChem, PC Dose response assay for dual activators of procaspase-3 and procaspase-7: Absorbance-based biochemical high throughput screening assay to identify activators of procaspase-7 PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-7
Synonyms:
Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase
Type:
Enzyme
Mol. Mass.:
34273.91
Organism:
Homo sapiens (Human)
Description:
P55210
Residue:
303
Sequence:
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
  
Inhibitor
Name:
BDBM79431
Synonyms:
MLS000519824 | SMR000130242 | [4-(4-fluorophenyl)-1-piperazinyl]-[1-(4-methoxyanilino)-4-isoquinolinyl]methanone | [4-(4-fluorophenyl)piperazin-1-yl]-[1-(4-methoxyanilino)isoquinolin-4-yl]methanone | [4-(4-fluorophenyl)piperazin-1-yl]-[1-[(4-methoxyphenyl)amino]isoquinolin-4-yl]methanone | [4-(4-fluorophenyl)piperazino]-[1-(p-anisidino)-4-isoquinolyl]methanone | cid_9550319
Type:
Small organic molecule
Emp. Form.:
C27H25FN4O2
Mol. Mass.:
456.5114
SMILES:
COc1ccc(Nc2ncc(C(=O)N3CCN(CC3)c3ccc(F)cc3)c3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: