Reaction Details Report a problem with these data
Target
Beta-adrenergic receptor kinase 1
Ligand
BDBM53267
Substrate
n/a
Meas. Tech.
Dose Response of inhibitors of GRK2 binding with RNA aptamer, Cherry Pick 1
EC50
33040±n/a nM
Citation
 PubChem, PC Dose Response of inhibitors of GRK2 binding with RNA aptamer, Cherry Pick 1 PubChem Bioassay (2011)[AID] 
Target
Name:
Beta-adrenergic receptor kinase 1
Synonyms:
ADRBK1 | ARBK1_HUMAN | BARK | BARK1 | Beta-ARK-1 | Beta-adrenergic receptor kinase 1 | G-protein coupled receptor kinase 2 | G-protein coupled receptor kinase 2 (GRK2) | GRK2
Type:
Enzyme
Mol. Mass.:
79581.30
Organism:
Homo sapiens (Human)
Description:
P25098
Residue:
689
Sequence:
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLVQRGSANGL
  
Inhibitor
Name:
BDBM53267
Synonyms:
4-[2-[(E)-[2,4-bis(oxidanylidene)-3-(2-oxidanylidene-2-pyrrolidin-1-yl-ethyl)-1,3-thiazolidin-5-ylidene]methyl]pyrrol-1-yl]benzoic acid | 4-[2-[(E)-[2,4-diketo-3-(2-keto-2-pyrrolidino-ethyl)thiazolidin-5-ylidene]methyl]pyrrol-1-yl]benzoic acid | 4-[2-[(E)-[2,4-dioxo-3-(2-oxo-2-pyrrolidin-1-ylethyl)-1,3-thiazolidin-5-ylidene]methyl]pyrrol-1-yl]benzoic acid | 4-[2-[(E)-[2,4-dioxo-3-[2-oxo-2-(1-pyrrolidinyl)ethyl]-5-thiazolidinylidene]methyl]-1-pyrrolyl]benzoic acid | 4-{2-[2,4-Dioxo-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-thiazolidin-(5E)-ylidenemethyl]-pyrrol-1-yl}-benzoic acid | MLS001219090 | SMR000605630 | cid_6490291
Type:
Small organic molecule
Emp. Form.:
C21H19N3O5S
Mol. Mass.:
425.458
SMILES:
OC(=O)c1ccc(cc1)-n1cccc1\C=C1\SC(=O)N(CC(=O)N2CCCC2)C1=O
Structure:
Search PDB for entries with ligand similarity: