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Target
Neurotensin receptor type 1
Ligand
BDBM79576
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1
EC50
19300±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 PubChem Bioassay (2011)[AID] 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM79576
Synonyms:
4,6-Dimethoxy-1H-indole-2-carboxylic acid [1-(2-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide | 4,6-dimethoxy-N'-[(E)-(5-methoxy-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]-1H-indole-2-carbohydrazide | 4,6-dimethoxy-N'-[(E)-(5-methoxy-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-1H-indole-2-carbohydrazide | 4,6-dimethoxy-N'-[(E)-(5-methoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-1H-indole-2-carbohydrazide | MLS000779102 | N'-[(E)-(6-keto-5-methoxy-cyclohexa-2,4-dien-1-ylidene)methyl]-4,6-dimethoxy-1H-indole-2-carbohydrazide | SMR000415778 | cid_6224576
Type:
Small organic molecule
Emp. Form.:
C19H19N3O5
Mol. Mass.:
369.3713
SMILES:
COc1cc(OC)c2cc([nH]c2c1)C(=O)NN=Cc1cccc(OC)c1O |w:16.17|
Structure:
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