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Target
Integrin alpha-L
Ligand
BDBM79606
Substrate
n/a
Meas. Tech.
Dose Response of Developing T Cell Immune Modulators with powder sourced compounds
EC50
51880±n/a nM
Citation
 PubChem, PC Dose Response of Developing T Cell Immune Modulators with powder sourced compounds PubChem Bioassay (2011)[AID] 
Target
Name:
Integrin alpha-L
Synonyms:
CD11 antigen-like family member A | ITAL_MOUSE | Itgal | Leukocyte adhesion glycoprotein LFA-1 alpha chain | Leukocyte function-associated molecule 1 alpha chain | Lfa-1 | Ly-15 | Lymphocyte antigen 15
Type:
Enzyme Catalytic Domain
Mol. Mass.:
128317.79
Organism:
Mus musculus
Description:
P24063
Residue:
1163
Sequence:
MSFRIAGPRLLLLGLQLFAKAWSYNLDTRPTQSFLAQAGRHFGYQVLQIEDGVVVGAPGEGDNTGGLYHCRTSSEFCQPVSLHGSNHTSKYLGMTLATDAAKGSLLACDPGLSRTCDQNTYLSGLCYLFPQSLEGPMLQNRPAYQECMKGKVDLVFLFDGSQSLDRKDFEKILEFMKDVMRKLSNTSYQFAAVQFSTDCRTEFTFLDYVKQNKNPDVLLGSVQPMFLLTNTFRAINYVVAHVFKEESGARPDATKVLVIITDGEASDKGNISAAHDITRYIIGIGKHFVSVQKQKTLHIFASEPVEEFVKILDTFEKLKDLFTDLQRRIYAIEGTNRQDLTSFNMELSSSGISADLSKGHAVVGAVGAKDWAGGFLDLREDLQGATFVGQEPLTSDVRGGYLGYTVAWMTSRSSRPLLAAGAPRYQHVGQVLLFQAPEAGGRWNQTQKIEGTQIGSYFGGELCSVDLDQDGEAELLLIGAPLFFGEQRGGRVFTYQRRQSLFEMVSELQGDPGYPLGRFGAAITALTDINGDRLTDVAVGAPLEEQGAVYIFNGKPGGLSPQPSQRIQGAQVFPGIRWFGRSIHGVKDLGGDRLADVVVGAEGRVVVLSSRPVVDVVTELSFSPEEIPVHEVECSYSAREEQKHGVKLKACFRIKPLTPQFQGRLLANLSYTLQLDGHRMRSRGLFPDGSHELSGNTSITPDKSCLDFHFHFPICIQDLISPINVSLNFSLLEEEGTPRDQKGRAMQPILRPSIHTVTKEIPFEKNCGEDKKCEANLTLSSPARSGPLRLMSSASLAVEWTLSNSGEDAYWVRLDLDFPRGLSFRKVEMLQPHSRMPVSCEELTEGSSLLTKTLKCNVSSPIFKAGQEVSLQVMFNTLLNSSWEDFVELNGTVHCENENSSLQEDNSAATHIPVLYPVNILTKEQENSTLYISFTPKGPKTQQVQHVYQVRIQPSAYDHNMPTLEALVGVPWPHSEDPITYTWSVQTDPLVTCHSEDLKRPSSEAEQPCLPGVQFRCPIVFRREILIQVTGTVELSKEIKASSTLSLCSSLSVSFNSSKHFHLYGSKASEAQVLVKVDLIHEKEMLHVYVLSGIGGLVLLFLIFLALYKVGFFKRNLKEKMEADGGVPNGSPPEDTDPLAVPGEETKDMGCLEPSGRVTRTKA
  
Inhibitor
Name:
BDBM79606
Synonyms:
4-[[2-[(7-chloranyl-4-oxidanylidene-pyrido[1,2-a]pyrimidin-2-yl)methylsulfanyl]-4-oxidanylidene-thieno[3,2-d]pyrimidin-3-yl]methyl]cyclohexane-1-carboxylic acid | 4-[[2-[(7-chloro-4-keto-pyrido[1,2-a]pyrimidin-2-yl)methylthio]-4-keto-thieno[3,2-d]pyrimidin-3-yl]methyl]cyclohexanecarboxylic acid | 4-[[2-[(7-chloro-4-oxo-2-pyrido[1,2-a]pyrimidinyl)methylthio]-4-oxo-3-thieno[3,2-d]pyrimidinyl]methyl]-1-cyclohexanecarboxylic acid | 4-[[2-[(7-chloro-4-oxopyrido[1,2-a]pyrimidin-2-yl)methylsulfanyl]-4-oxothieno[3,2-d]pyrimidin-3-yl]methyl]cyclohexane-1-carboxylic acid | VU0146817-3 | cid_4170435
Type:
Small organic molecule
Emp. Form.:
C23H21ClN4O4S2
Mol. Mass.:
517.02
SMILES:
OC(=O)C1CCC(Cn2c(SCc3cc(=O)n4cc(Cl)ccc4n3)nc3ccsc3c2=O)CC1 |(4.41,-5.21,;4.41,-3.67,;3.08,-2.9,;5.75,-2.9,;7.08,-3.67,;8.41,-2.9,;8.41,-1.36,;9.75,-.59,;9.75,.95,;11.08,1.72,;12.42,.95,;13.75,1.72,;15.08,.95,;15.08,-.59,;16.42,-1.36,;16.42,-2.9,;17.75,-.59,;19.13,-1.41,;20.52,-.62,;21.85,-1.4,;20.52,.98,;19.13,1.77,;17.75,.95,;16.42,1.72,;11.08,3.26,;9.75,4.03,;9.43,5.53,;7.9,5.69,;7.28,4.29,;8.41,3.26,;8.41,1.72,;7.08,.95,;7.08,-.59,;5.75,-1.36,)|
Structure:
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