Reaction Details Report a problem with these data
Target
Tropomyosin alpha-1 chain
Ligand
BDBM51191
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
2177±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM51191
Synonyms:
(Z)-[2-keto-4-(3-methylpyridin-1-ium-1-yl)-3-thiazolin-5-ylidene]methanolate | (Z)-[4-(3-methyl-1-pyridin-1-iumyl)-2-oxo-5-thiazolylidene]methanolate | (Z)-[4-(3-methylpyridin-1-ium-1-yl)-2-oxidanylidene-1,3-thiazol-5-ylidene]methanolate | (Z)-[4-(3-methylpyridin-1-ium-1-yl)-2-oxo-1,3-thiazol-5-ylidene]methanolate | MLS000710654 | SMR000280421 | cid_16195045
Type:
Small organic molecule
Emp. Form.:
C10H8N2O2S
Mol. Mass.:
220.248
SMILES:
Cc1ccc[n+](c1)-c1[n-]c(=O)sc1C=O
Structure:
Search PDB for entries with ligand similarity: