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Target
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM48625
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
42800±n/a nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
  
Inhibitor
Name:
BDBM48625
Synonyms:
(4Z)-2-ethoxy-4-[mercapto(4-morpholinyl)methylidene]-1-cyclohexa-2,5-dienone | (4Z)-2-ethoxy-4-[mercapto(morpholino)methylene]cyclohexa-2,5-dien-1-one | (4Z)-2-ethoxy-4-[morpholin-4-yl(sulfanyl)methylidene]cyclohexa-2,5-dien-1-one | MLS000108685 | SMR000104638 | cid_5344185
Type:
Small organic molecule
Emp. Form.:
C13H17NO3S
Mol. Mass.:
267.344
SMILES:
CCOc1cc(ccc1O)C(=S)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: