Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM71291
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
47200±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM71291
Synonyms:
(5E)-3-benzyl-5-(2,3-dihydroxybenzylidene)-2-thioxo-thiazolidin-4-one | (5E)-3-benzyl-5-[(2,3-dihydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | (5E)-5-[(2,3-dihydroxyphenyl)methylidene]-3-(phenylmethyl)-2-sulfanylidene-4-thiazolidinone | (5E)-5-[[2,3-bis(oxidanyl)phenyl]methylidene]-3-(phenylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one | 3-benzyl-5-(2,3-dihydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one | MLS001163339 | SMR000497264 | cid_2291671
Type:
Small organic molecule
Emp. Form.:
C17H13NO3S2
Mol. Mass.:
343.42
SMILES:
Oc1cccc(\C=C2\SC(=S)N(Cc3ccccc3)C2=O)c1O
Structure:
